The film begins with Tiger (Salman Khan), conducting a mission in northern Iraq.The mission is accompanied by a barrage of gunshots and chase sequence.Tiger kills a bunch of agents after bumping off one of his own men, who defected to Pakistan’s ISI.Tiger lived in a government employee neighbourhood about whom his neighbours know nothing. It is because he is India's top spy, an officer with research and analysis wing (RAW), India's external intelligence agency and called Tiger in his codename. Tiger reports to Shenoy (Girish Karnad) in New Delhi after every field mission for the last 12 years. Then Tiger is sent on a mission to Dublin, Ireland to observe a scientist of Indian origin, Professor Kidwai (Roshan Seth), who teaches at the Trinity College and suspect of sharing his finding with Pakistan defence establishment. Fellow RAW agent, Gopi (Ranvir Shorey) accompanies Tiger on this mission. Tiger attempts to meet the scientist but is not successful although he meet with scientist's caretaker Zoya (Katrina Kaif) who is studying at a fictional dance academy. He tries to befriend Zoya and as he begins to get closer to Zoya, He begins to discover his human side. Despite repeated warnings from Tiger’s associate Gopi not to fall in love, For the first time in his life, Tiger falls in love. Then begins a journey that Tiger and Zoya embark upon battling the dark world of intelligence and espionage that forbids them from falling in love and takes them from Dublin to Istanbul, Kazakhstan and Chile.